| Co-relationship Study between Follicular Fluid Oxidative Stress and the ICSI outcome |
| Paper ID : 1071-ISCBAS |
| Authors |
|
Marwa Mahmoud Neseem * Scientific assistant at the international Islamic center for research and population studies |
| Abstract |
| Co-relationship Study between Follicular Fluid Oxidative Stress and the ICSI Outcome Marwa Mahmoud Abdallah (1), Nehal Ali Abu Elnaga (2), Mohamed Sobhy Nasr (3) and Eman Anwar Hassan (4) Bachelor of Science, Department of Zoology/Chemistry, Zakazik University. Prof. of Embryology, Faculty of Science, Al-Azhar University (girl's branch). Lecturer of Histology, Faculty of Medicine, Al-Azhar University. Assistant professor of embryology, International Islamic center for population studies and research, Al-Azhar University. Cairo, Egypt. Abstract Background: DNA oxidative stress (OS) exposure is a possible pathogenic mechanism for congenital anomalies, especially In vitro. The mechanical manipulation of both the ovum and sperm may increase the presence of different OS biomarkers in the follicular fluid (FF), such as variations in their concentrations and response to ovulation. Aim of work: assessment of the relationship between the levels of reactive oxygen species (ROS) in the follicular fluid of women undergoing IVF/ICSI and embryo quality in the respective cycles. Methods: This work includes 150 cases undergoing controlled ovarian stimulation and analyses for ROS and lipid peroxidation (LPO) in follicular fluid, which are divided into three groups: normal females partner group (50 cases), obese females partner group (50 cases), and PCO females partner group (50 cases). Results: After adjusting for age as a factor, there was a significant positive correlation between ROS and the number of follicles on the day of HCG administration, the number of oocytes retrieved, fertilization rate as well as embryo development. Conclusion: Oxidative stress's Parameters may influence metabolic activity within the follicle. |
| Keywords |
| Keywords: Follicular fluid, oxidative stress, assisted reproductive technology, intracytoplasmic sperm injection. |
| Status: Abstract Accepted (Poster Presentation) |