EFFECT OF CUCUMEROPSIS MANNII SEED OIL (CMSO) ON CAT AND GPx IN BISPENOL A INDUCED TRANSGENERATIONAL TESTICULAR DAMAGE IN MALE RAT.

Paper ID : 1092-ISCBAS

Authors

Ogechi Cecilia Ofor * Faulty of science

Abstract

AbstractThe study investigated the effect of cucumeropsis manni seed oil(CMSO) in catalase and glutathione peroxidase in bisphenol A induced trans-generational testicular damage in male rats. A total of thirty six female albino wistar rats of 9 weeks old were used for this study. The rats were randomly distributed into six (6) experimental groups of A, B, C, D, E and F with six rats in each group. Group A, B and C were control groups while groups D, E, and F were the treatment groups. All the groups were placed with 2 male rats for 1 week. Detection of vaginal plugs in the female rats within the week were noted and designated as embryo day (ED) 0.5. The result of the study revealed exposure of a BPA to pregnant rats were significantly (p<0.5) reduced catalase and glutathione peroxidase concentration in the testes of the first filial generation of male rats. However, activities of catalase and glutathione peroxidase in the testis of the first filial generation of male rats were significantly (p<0.05) elevated when BPA and CMSO were co-administered to their pregnant mothers. This suggests that Perinatal and developmental exposure to BPA can induce oxidative stress and cause adverse effect on sperm maturation and quality.

Keywords

Testicular cancer caused by Bisphenol A

Status: Abstract Accepted (Oral Presentation)